Kariometry Parameters of Hepatocytes on Different Stages of Fibrosis and Portal Hypertension in Patients with Chronic Diffuse Liver Diseases

Autor:	Yu.M. Stepanov, Yu.A. Haidar, V.I. Didenko, H.Yu. Arzhanova
Jazyk:	English<br />Ukrainian
Rok vydání:	2015
Předmět:	chronic diffuse liver diseases karyometric parameters of hepatocytes nuclear cytoplasmic relations portal hypertension Diseases of the digestive system. Gastroenterology RC799-869
Zdroj:	Gastroenterologìa, Vol 49, Iss 4.58, Pp 62-67 (2015)
Druh dokumentu:	article
ISSN:	2308-2097 2518-7880
DOI:	10.22141/2308-2097.4.58.2015.81547
Popis:	Thirty three patients have been examined: in two cases in liver biopsy material there was no evidence of fibrosis, 10 persons had stage F1 fibrosis, 10 — F2, 6 — F3 and 5 — F4 in accordance with METAVIR scale. Hepatocyte nuclei area has been measured, as well as nuclear cytoplasmic relations, ellipticity coefficient and hepatocyte nuclei deformation factor have been calculated. Correlations between hepatocytes karyometric parameters reflect subcellular mechanisms of impairment in chronic diffuse liver diseases on different stages of the portal hypertension manifestation and liver fibrosis. Correlation between enhanced diameter of sinusoids and aggrevation of portal hypertension manifestations has been registered.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/624e92e5945b4b7fa20d007385ec1d6b Zobrazit plný text záznamu View record in DOAJ