Clinical value of peripheral blood miR-21 and miR-486 combined with CT forearly cancer diagnosis in pulmonary nodulessmoking

Autor:	Zheng Wang, Jinfeng Liu, Qiang Liu, Yingchun Ren, Qiang Wang, Qing Tian, Zhijie Li, Huining Liu
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	miR-21 and miR-486 Peripheral blood Early CT diagnosis Pulmonary nodules Surgery RD1-811 Anesthesiology RD78.3-87.3
Zdroj:	Journal of Cardiothoracic Surgery, Vol 19, Iss 1, Pp 1-8 (2024)
Druh dokumentu:	article
ISSN:	1749-8090
DOI:	10.1186/s13019-024-03028-8
Popis:	Abstract Purpose This study aimed to investigate the clinical significance of combining peripheral blood miR-21 and miR-486 with CT for the early cancer diagnosis in pulmonary nodules. Methods A total of 215 patients diagnosed with isolated pulmonary nodules with a history of smoking were selected as researchsubjects. 30 healthy volunteers with a history of smoking were recruitedas the control group.The selection of subjectswas based on the presence of isolated pulmonary nodules detected on chest CT scans. The training set consisted of 65 patients with lung nodules and 30 healthy smokers, while the verification setincluded 150 patients with lung nodules. Results Compared with the control group, the plasma expression level of miR-210 was significantly higher in the group of patients with benign pulmonary nodules (P
Databáze:	Directory of Open Access Journals
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