Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells

Autor: Chen Yijie, Sha Wenqi, Zhang Yifan, Kou Wanyi, Yang Liu, Guo Ruixin, Li Chenyang, Zhao Junjie, Wang Zhenghui
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Open Medicine, Vol 19, Iss 1, Pp 2041731420943839-73 (2024)
Druh dokumentu: article
ISSN: 2391-5463
DOI: 10.1515/med-2024-1073
Popis: Dysregulation of chondrogenic differentiation is associated with osteoarthritis (OA). The myokine irisin is beneficial in OA treatment; yet, the underlying mechanism is not fully understood. Long noncoding RNAs (lncRNAs) act as important regulators of chondrocyte differentiation. This study was conducted to address the role of lncRNAs in mediating irisin-induced chondrocyte differentiation.
Databáze: Directory of Open Access Journals