| Popis: |
Objectives: Pain, fever and inflammation associated with protozoan infections caused by Trypanosomes, Babesia, Entamoeba, Leishmania and Pneumocystis have necessitated the search for polypharmacy,that could be used for treatment of protozoan infections in dogs. Methods: Randomized cross-over controlled trial was adopted for kinetic study of piroxicam (3.5 mg/kg) and piroxicam (3.5 mg/kg) administered with diminazene aceturate (3.5 mg/kg) in Nigerian indigenous dogs. Ten dogs comprised 5 males and females, each of about 8 ± 2 months and weighed 10 ± 0.5 kg were administered piroxicam, after one month the dogs were administered piroxicam and diminazene aceturate at different thigh muscles. Single dose was administered to avoid toxicity. Blood samples were collected at 0, 0.08, 0.25, 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0, 10, 12, 24, 48, 72 and 96 h for plasma analysis of piroxicam. Results: Findings have shown that piroxicam was significantly (p |
