Effect of Parenteral Antioxidant Supplementation During the Dry Period on Postpartum Glucose Tolerance in Dairy Cows

Autor: A. Abuelo, V. Alves‐Nores, J. Hernandez, R. Muiño, J.L. Benedito, C. Castillo
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Journal of Veterinary Internal Medicine, Vol 30, Iss 3, Pp 892-898 (2016)
Druh dokumentu: article
ISSN: 1939-1676
0891-6640
DOI: 10.1111/jvim.13922
Popis: Background Exacerbated postparturient insulin resistance (IR) has been associated with several pathologic conditions in dairy cattle. Oxidative stress (OS) plays a causative role in IR in humans, and an association, but not direct relationship, between OS and IR recently has been reported in transition dairy cattle. Hypothesis Supplementation with antioxidants shortly before calving improves glucose tolerance after parturition in dairy cattle. Animals Ten late‐pregnant Holstein cows entering their 2nd to 5th lactation. Methods Randomized placebo‐controlled trial: 15 ± 2 days before expected calving, the treatment group received an injection of DL‐alpha‐tocopheryl acetate at a dosage of 6 mg/kg body weight (BW) and 0.06 mg/kg BW of sodium selenite, and the control group was injected with isotonic saline. During the first week after calving, both groups underwent glucose tolerance testing (0.25 g glucose/kg BW). Commercial assays were used to quantify the concentrations of glucose, insulin, nonesterified fatty acids (NEFA), beta‐hydroxybutyrate, and markers of redox status in blood. Data were analyzed using the Mann–Whitney U‐test (α = 0.05). Results Supplemented cows showed a lower risk for OS, as reflected by a lower OS index (P = .036), different areas under the curve for the concentrations of glucose (P < .01), insulin (P = .043), and NEFA (P = .041), more rapid elimination rates (P = .080,
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