Breast Carcinoma; Human Epidermal Growth Factor Receptor-2 (HER-2) and Grading Correlation
| Autor: | Seyed Abbas Mirmalek, Fatemeh Elham Kani, Arianeb Mehrabi, Mehdi Chavoshi-Nejad, Seyed Alireza Salimi-Tabatabaee, Yekta Parsa, Soheila Yadollah-Damavandi, Tina Parsa, Amin Aidun |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | International Journal of Travel Medicine and Global Health, Vol 3, Iss 3, Pp 95-97 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2322-1100 2476-5759 |
| DOI: | 10.20286/ijtmgh-030395 |
| Popis: | Introduction: Overexpression of Human Epidermal Growth factor Receptor-2 (HER-2) is one of the most important prognostic and predictive factors of breast cancer, observed in 25% - 30% of breast carcinoma patients leading to poor prognosis and feasible anti HER-2 antibody drugs. The objective of this study was to evaluate the HER-2 frequency in target population and its correlation with histologic grade as well as tumor pathology, estrogen receptor (ER) and P53 in our patients. Methods: A total of 300 cases (all female) aged 24- 80 year, were randomly selected from patients who were admitted in two of the Tehran University of Medical Sciences affiliated centers (Emam Khomeini Cancer Institute and Shariati hospital) over a 2-year period (2013-2014). Assessment of tumors for HER-2, P53, ER, pathological type and histologic grade was performed. HER-2 over expression defined as three plus (+++) in immunohistochemistry (IHC). Results: The mean age was 49.6±11 years. HER-2 over expression was seen in 34% of the patients. Significant correlations were found between HER-2+, P53+ and high histologic grade and ER (PConclusion: Co-expression of several poor prognostic biomarkers in breast cancer (HER-2 +, P53 +, ER- , high grade) may predict more aggressive phenotype, worse disease and lower overall survival in these patients. |
| Databáze: | Directory of Open Access Journals |
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