Systematic review and evidence gap assessment of the clinical, quality of life, and economic burden of alpha‐thalassemia

Autor: Khaled M. Musallam, Vip Viprakasit, Louise Lombard, Keely Gilroy, Amey Rane, Lydia Vinals, Candice Tam, Maria Rizzo, Thomas D. Coates
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: eJHaem, Vol 5, Iss 3, Pp 541-547 (2024)
Druh dokumentu: article
ISSN: 2688-6146
DOI: 10.1002/jha2.882
Popis: Abstract A recent evidence gaps assessment of the clinical, health‐related quality of life, and economic burden associated with α‐thalassemia is lacking. We conducted a systematic literature review (SLR) following the methodological and reporting requirements of the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses and the Cochrane Handbook for Systematic Reviews, using available literature over the past decade. This SLR identified a considerable evidence gap with regard to understanding the current burden of α‐thalassemia as evident from paucity of studies published in the past 10 years. The limited data available still indicate that patients with α‐thalassemia experience substantial morbidity and quality of life/economic burden that is generally comparable to patients with β‐thalassemia.
Databáze: Directory of Open Access Journals