| Autor: |
Ahmed Mohamed Mohamed Youssef, Thabet Hasan Ahmad Althneibat, Doaa Ahmed Mohamed Maaty, Yasser Gaber |
| Jazyk: |
English<br />Korean |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacopuncture, Vol 27, Iss 3, Pp 223-233 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2093-6966 |
| DOI: |
10.3831/KPI.2024.27.3.223 |
| Popis: |
Objectives: The phytochemicals in the aerial parts of Euphorbia paralias (also known as Sea Spurge) and their anti-inflammatory and antimicrobial activities were investigated.Methods: The methanolic extract was characterized using GC-MS and HPLC techniques. The anti-inflammatory feature was estimated through a Human Red Blood Cell (HRBC) membrane stabilization technique, while the antimicrobial feature was evaluated by the disc diffusion agar technique, minimum bactericidal concentration, and minimum inhibitory concentration (MIC) via micro-broth dilution method.Results: The GC/MS results demonstrated the existence of various phytochemicals, such as n-hexadecenoic acid, cis-11-eicosenoic acid, and methyl stearate, recognized for their anti-inflammatory and antibacterial features. The similarity of the phytochemical composition with other Euphorbia species emphasizes the genus-wide similarity. The antiinflammatory activity exhibited a noteworthy inhibitory effect comparable to the reference drug indomethacin. The extract’s antimicrobial potential was tested against a range of microorganisms, demonstrating significant action against Gram-positive bacteria and Candida albicans . The quantification of total phenolics and flavonoids further supported the therapeutic potential of the extract.Conclusion: The methanolic extract from E. paralias emerges as a successful natural source of important active constituents with potential applications as anti-inflammatory and antimicrobial agents. This research provides a first step to valorize Euphorbia paralias insights as a source of worthwhile phytochemicals that have potential applications in the pharmaceutical industry. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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