| Autor: |
Alejandro Martín-Quirós, Charbel Maroun-Eid, José Avendaño-Ortiz, Roberto Lozano-Rodríguez, Jaime Valentín Quiroga, Verónica Terrón, Karla Montalbán-Hernández, Miguel A. García-Garrido, Elena Muñoz del Val, Álvaro del Balzo-Castillo, Carolina Rubio, Carolina Cubillos-Zapata, Luis A. Aguirre, Eduardo López-Collazo |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Biomedicine Hub, Vol 6, Iss 1, Pp 48-58 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2296-6870 |
| DOI: |
10.1159/000514727 |
| Popis: |
We report the disparate clinical progression of a couple infected by SARS-CoV-2 based on their immune checkpoint (IC) levels and immune cell distribution in blood from admission to exitus in patient 1 and from admission to discharge and recovery in patient 2. A detailed clinical follow-up accompanied by a longitudinal analysis of immune phenotypes and IC levels is shown. The continuous increase in the soluble IC ligand galectin-9 (Gal-9) and the increment in T-cell immunoglobulin and mucin domain-containing 3 (TIM-3) protein in T cells in patient 1 suggests an activation of the Gal-9/TIM-3 axis and, subsequently, a potential cell exhaustion in this patient that did not occur in patient 2. Our data indicate that the Gal-9/TIM-3 axis could be a potential target in this clinical setting, along with a patent effector memory T-cell reduction. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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