Three‐arm clinical trial of improved flour targeting intestinal microbiota (MALINEA)

Autor: Muriel Vray, Laura Tondeur, Boris G. Hedible, Rindra Vatosoa Randremanana, Alexandre Manirakiza, Ramatoulaye Hamidou Lazoumar, Cassandre Van Platen, Antonio Vargas, André Briend, Ronan Jambou
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Maternal and Child Nutrition, Vol 20, Iss 3, Pp n/a-n/a (2024)
Druh dokumentu: article
ISSN: 1740-8709
1740-8695
DOI: 10.1111/mcn.13649
Popis: Abstract The main objective of this project was to compare in the field conditions two strategies of re‐nutrition of children with moderate acute malnutrition (MAM) aged from 6 to 24 months, targeting the microbiota in comparison with a standard regimen. A three‐arm, open‐label, pragmatic randomised trial was conducted in four countries (Niger, CAR, Senegal and Madagascar). Children received for 12 weeks either fortified blended flour (FBF control) = arm 1, or FBF + azithromycin (oral suspension of 20 mg/kg/day daily given with a syringe) for the first 3 days at inclusion = arm 2 or mix FBF with inulin/fructo‐oligosaccharides (6 g/day if age ≥12 months and 4 g if age
Databáze: Directory of Open Access Journals
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