| Autor: |
Alessandra Cataldo, Douglas G. Cheung, John P. Hagan, Matteo Fassan, Sukhinder Sandhu-Deol, Carlo M. Croce, Gianpiero Di Leva, Marilena V. Iorio |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Non-Coding RNA, Vol 10, Iss 1, p 4 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2311-553X |
| DOI: |
10.3390/ncrna10010004 |
| Popis: |
MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and maturation. However, a functional role in this process has not been clearly demonstrated. We generated an miR-205 knockout in the FVB/N mouse strain, which is viable and characterized by enhanced mammary gland development. Indeed, mammary glands of miR-205−/− female mice at different ages (1.5 and 5.5 months) show increased outgrowth and branching. This evidence is consistent with our previously reported data demonstrating the direct miR-205-mediated targeting of HER3, a master regulator of mammary gland development, and the oncosuppressive activity of this microRNA in different types of breast cancer. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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