Combined Hypertrophic Pachymeningitis and Cerebral Venous Thrombosis in a Case of Granulomatosis with Polyangiitis

Autor:	Tadahiro Kuribayashi, Yasuhiro Manabe, Shunya Fujiwara, Yoshio Omote, Hisashi Narai, Koji Abe
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Hypertrophic pachymeningitis Cerebral venous thrombosis Granulomatosis with polyangiitis Antineutrophil cytoplasmic antibody Central nervous system Neurology. Diseases of the nervous system RC346-429
Zdroj:	Case Reports in Neurology, Vol 11, Iss 2, Pp 252-255 (2019)
Druh dokumentu:	article
ISSN:	1662-680X
DOI:	10.1159/000502284
Popis:	We report a rare case of hypertrophic pachymeningitis (HP) and cerebral venous thrombosis associated with proteinase-3-antineutrophil cytoplasmic antibody (PR3-ANCA)-positive granulomatosis with polyangiitis (GPA). A 58-year-old male developed left headache after exudative otitis media. The laboratory data were positive for PR3-ANCA. Brain magnetic resonance imaging revealed bilateral paranasal sinusitis, left frontal lobe edema, and a thick dura mater with abnormal enhancement in the frontotemporal lobe. Magnetic resonance venography detected stenosis of the superior sagittal sinus. The patient was successfully treated with glucocorticoid, cyclophosphamide, and apixaban. Contrast neuroimaging should be performed for patients who present with unexplained headache, especially with middle ear and paranasal inflammation. These symptoms should be considered as GPA-related HP and cerebral venous thrombosis.
Databáze:	Directory of Open Access Journals
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