Intraoperative blood loss independently predicts survival and recurrence after resection of colorectal cancer liver metastasis.

Autor: Wu Jiang, Yu-Jing Fang, Xiao-Jun Wu, Fu-Long Wang, Zhen-Hai Lu, Rong-Xin Zhang, Pei-Rong Ding, Wen-Hua Fan, Zhi-Zhong Pan, De-Sen Wan
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: PLoS ONE, Vol 8, Iss 10, p e76125 (2013)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0076125
Popis: BACKGROUND: Although numerous prognostic factors have been reported for colorectal cancer liver metastasis (CRLM), few studies have reported intraoperative blood loss (IBL) effects on clinical outcome after CRLM resection. METHODS: We retrospectively evaluated the clinical and histopathological characteristics of 139 patients who underwent liver resection for CRLM. The IBL cutoff volume was calculated using receiver operating characteristic curves. Overall survival (OS) and recurrence free survival (RFS) were assessed using the Kaplan-Meier and Cox regression methods. RESULTS: All patients underwent curative resection. The median follow up period was 25.0 months (range, 2.1-88.8). Body mass index (BMI) and CRLM number and tumor size were associated with increased IBL. BMI (P=0.01; 95% CI = 1.3-8.5) and IBL (P500mL were 71%, 33%, and 0%, respectively (P
Databáze: Directory of Open Access Journals