Investigating the Effect of Vitamin D Supplementation on Maternal Serum 25(OH)D Levels

Autor: Zahra Moudi, Zahra Ayati, Hossein Ansari, Seyed Mehdi Tabatabaei, Mahdieh Sheikhi
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Midwifery & Reproductive Health, Vol 9, Iss 2, Pp 2687-2696 (2021)
Druh dokumentu: article
ISSN: 2345-4792
DOI: 10.22038/jmrh.2021.54094.1661
Popis: Background & aim: Although evidence confirms the importance of vitamin D supplementation in pregnancy, there is still a debate over the adequate daily doses of vitamin D intake. This study aimed to investigate the effect of 400 and 1,000 IU vitamin D/day on maternal serum 25 (OH) D levels. Methods: This quasi-experimental study was carried out on 74 healthy pregnant women between June 12 and September 22, 2019. The intervention group (n=44) received 1,000 IU vitamin D/day from 8 to 10 weeks of pregnancy for 17 weeks, while the control group (n=39) took multivitamin supplements (400 IU vitamin D/day) from 16 weeks of pregnancy for 12 weeks. Maternal serum 25 (OH) D levels were measured at 25-28 weeks of gestation. Data were analyzed in SPSS software (version 21) through the Chi-square, Student’s t-test, Mann-Whitney U, and linear regression tests. Results: There was no significant difference between the two groups at the beginning of the study in terms of 25 (OH) D concentration (P=0.23). The intake of 1,000 IU vitamin D/day had a significant (β=0.28, p
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