The improved photostability of naproxen in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin
| Autor: | Ilić-Stojanović Snežana S., Nikolić Vesna D., Nikolić Ljubiša B., Zdravković Aleksandar S., Kapor Agneš J., Popsavin Mirjana M., Petrović Slobodan D. |
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| Jazyk: | English<br />Serbian |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Hemijska Industrija, Vol 69, Iss 4, Pp 361-370 (2015) |
| Druh dokumentu: | article |
| ISSN: | 0367-598X 2217-7426 13112805 |
| DOI: | 10.2298/HEMIND131128050I |
| Popis: | The aim of this work was the preparation of the inclusion complex of naproxen with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) in order to improve the physical and chemical properties of naproxen. The molecular inclusion complexes of naproxen with HP-β-CD were prepared by using the co-precipitation method in the solid state with the molar ratio of 1:1. The structure of the obtained complex was characterized by using FTIR, 1H NMR, UV-Vis and XRD methods. The testing of naproxen photostability by the UV-Vis method indicated the degradation to aromatic ketone, 2-acetyl-6-methoxynaphthalene. FTIR analysis showed that the degradation started 15 days after the exposure of naproxen to daylight while the inclusion complex of naproxen: 2-hydroxypropyl-β-cyclodextrin was photostable for a period of 30 days. [Projekat Ministarstva nauke Republike Srbije, br. TR 34012] |
| Databáze: | Directory of Open Access Journals |
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