| Autor: |
Mohammad N. Soltani Rad, Ali Khalafi-Nezhad, Somayeh Behrouz |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, p 49 (2010) |
| Druh dokumentu: |
article |
| ISSN: |
1860-5397 |
| DOI: |
10.3762/bjoc.6.49 |
| Popis: |
The syntheses of novel hydrazono acyclic nucleosides similar to miconazole scaffolds are described. In this series of acyclic nucleosides, pyrimidine as well as purine and other azole derivatives replaced the imidazole function in miconazole and the ether group was replaced with a hydrazone moiety using phenylhydrazine. To interpret the dominant formation of (E)-hydrazone derivatives rather than (Z)-isomers, PM3 semiempirical quantum mechanic calculations were carried out which indicated that the (E)-isomers had the lower heats of formation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
