A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence

Autor:	D. J. Kemp, J. Thompson, D. A. Barnes, T. Triglia, F. Karamalis, C. Petersen, G. V. Brown, K. P. Day
Jazyk:	angličtina
Rok vydání:	1992
Předmět:	chromosome deletion cytoadherence Plasmodium falciparum pathology PfEMP1 Microbiology QR1-502 Infectious and parasitic diseases RC109-216
Zdroj:	Memorias do Instituto Oswaldo Cruz, Vol 87, Pp 85-89 (1992)
Druh dokumentu:	article
ISSN:	0074-0276 1678-8060
DOI:	10.1590/S0074-02761992000700011
Popis:	Many lines of Plasmodium falciparum undrgo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis. Selection of cytoadherent cells from a mixed population co-selects for those with an undeleted chromosome 9 and selected cells produce gametocytes. The deletion also results in loss of expression of PfEMP1, the putative cytoadherence ligand, suggesting PfEMP1 or a regulatory gene controlling PfEMP1 expression and gametocytogenesis may be encoded in this region. We have isolated several markers for the deleted region and are currently using a YAC-P. falciparum library to investigate this region of the genome in detail.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/61d888b5f05549ceac9f4d512ed9af6d Zobrazit plný text záznamu View record in DOAJ