| Autor: |
Esther J.M. Taks, Simone J.C.F.M. Moorlag, Konstantin Föhse, Elles Simonetti, Christa E. van der Gaast-de Jongh, Cornelis H. van Werkhoven, Marc J.M. Bonten, Jaap ten Oever, Marien I. de Jonge, Janneke H.H.M. van de Wijgert, Mihai G. Netea |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
iScience, Vol 26, Iss 11, Pp 108062- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2023.108062 |
| Popis: |
Summary: Earlier studies showed that BCG vaccination improves antibody responses of subsequent vaccinations. Similarly, in older volunteers we found an increased IgG receptor-binding domain (RBD) concentration after SARS-CoV-2 infection if they were recently vaccinated with BCG. This study aims to assess the effect of BCG on the serum antibody concentrations induced by COVID-19 vaccination in a population of adults older than 60 years. Serum was collected from 1,555 participants of the BCG-CORONA-ELDERLY trial a year after BCG or placebo, and we analyzed the anti-SARS-CoV-2 antibody concentrations using a fluorescent-microsphere-based multiplex immunoassay. Individuals who received the full primary COVID-19 vaccination series before serum collection and did not test positive for SARS-CoV-2 between inclusion and serum collection were included in analyses (n = 945). We found that BCG vaccination before first COVID-19 vaccine (median 347 days [IQR 329–359]) did not significantly impact the IgG RBD concentration after COVID-19 vaccination in an older European population. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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