Membrane effects of Cocoa Procyanidins in Liposomes and Jurkat T Cells

Autor:	SANDRA V. VERSTRAETEN, PATRICIA I. OTEIZA, CÉSAR G. FRAGA
Jazyk:	angličtina
Rok vydání:	2004
Předmět:	Epicatechin free radicals lipid oxidation membrane fluidity membrane permeability procyanidins Biology (General) QH301-705.5
Zdroj:	Biological Research, Vol 37, Iss 2, Pp 293-300 (2004)
Druh dokumentu:	article
ISSN:	0716-9760 0717-6287
Popis:	We investigated the effects of the interaction between flavanols and related procyanidins (dimer to hexamer) with both cell and synthetic membranes, on bilayer fluidity and susceptibility to oxidation. Cocoa derived dimers (0.05 to 1 µg/ml) protected Jurkat T cells from AMVN-mediated oxidation and increased plasma membrane fluidity. These effects occurred in a concentration- and chain length-dependent manner. In liposomes, procyanidins prevented the Fe2+-induced permeabilization of the membrane. Together, these results support the hypothesis that procyanidins could interact with the polar headgroup of lipids, increasing membrane fluidity and also, preventing the access of molecules that could affect membrane integrity
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/61c06fb677164831999dd48c9b7ccf76 Zobrazit plný text záznamu View record in DOAJ