Knockdown circTRIM28 enhances tamoxifen sensitivity via the miR-409-3p/HMGA2 axis in breast cancer

Autor: Shiyong Yang, Changwu Zou, Yuxin Li, Xianguo Yang, Wei Liu, Guannan Zhang, Nina Lu
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Reproductive Biology and Endocrinology, Vol 20, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 1477-7827
DOI: 10.1186/s12958-022-01011-3
Popis: Highlights 1. The expression of circTRIM28 was upregulated in BC. 2. Silencing circTRIM28 enhanced tamoxifen sensitivity and cell apoptosis, whereas curbed cell proliferation, cell migration and invasion in BC cells. 3. CircTRIM28 expedited BC by targeting miR-409-3p. 4. MiR-409-3p repressed BC by retarding HMGA2.
Databáze: Directory of Open Access Journals
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