Histologically Overt Stromal Response and the Risk of Progression after Radical Prostatectomy for Prostate Cancer

Autor: Mutlay Sayan, Yetkin Tuac, Samet Kucukcolak, Mary D. Rowan, Grace K. Pratt, Cagdas Aktan, Elza Tjio, Dilara Akbulut, Shalini Moningi, Jonathan E. Leeman, Peter F. Orio, Paul L. Nguyen, Anthony V. D’Amico, Mahmut Akgul
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Cancers, Vol 16, Iss 10, p 1871 (2024)
Druh dokumentu: article
ISSN: 16101871
2072-6694
DOI: 10.3390/cancers16101871
Popis: Purpose: Given the variable clinical course of prostate cancer and the limitations of current prognostic factors, this study was conducted to investigate the impact of a histologically overt stromal response (HOST-response) to prostate cancer on clinical outcomes after radical prostatectomy. Methods: This retrospective analysis utilized The Cancer Genome Atlas (TCGA) to evaluate data from individuals with a confirmed diagnosis of prostate cancer who underwent radical prostatectomy and had available pathology slides. These slides were assessed for the presence of a HOST-response, similar to desmoplasia. The primary endpoint was progression-free survival (PFS). A multivariable competing risk regression analysis was used to assess whether a significant association existed between HOST-response and PFS, adjusting for known prostate cancer prognostic factors. Results: Among the 348 patients analyzed, 166 (47.70%) demonstrated a HOST-response. After a median follow-up of 37.87 months (IQR: 21.20, 65.50), the presence of a HOST-response was significantly associated with a shorter PFS (SDHR, 2.10; 95% CI, 1.26 to 3.50; p = 0.004), after adjusting for covariates. Conclusions: HOST-response in prostate cancer patients treated with radical prostatectomy is significantly associated with reduced PFS, suggesting a potential benefit from adjuvant therapy and highlighting the need for further investigation in a prospective randomized clinical trial.
Databáze: Directory of Open Access Journals
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