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The purpose of the study – the optimization of clinical diagnosis of chronic course of Ixodes tick-borne borreliosis based on indicators of immune and cytokine status of patients.Materials and Methods: clinical and immunological study of patients with chronic Ixodes tick-borne borreliosis in the Krasnoyarsk region. The observations were made on 205 patients for 1,5 years. The diagnosis was based on clinical and epidemiological data confirmed the identification of specific antibodies to borrelia by ELISA. The indices of cellular and humoral immune system, phagocytosis, cytokine (interleukin-1β, 4, 8 , tumor necrosis factor-α).Results: Show Part chronicity of infection after an noneritemic form of the disease (37,5%) and combined forms of Ixodes tick-borne borreliosis with tick-borne encephalitis (33,2%). Clinical manifestations were characterized by the involvement in the pathological process of the musculoskeletal system (42,9%) and combined lesions to the nervous system (38.5%). A rare variant of the chronic course of borreliosis was central nervous system as the onset of the disease (3,5%). Common infectious syndrome relapse accompanied by autonomic dysfunction with prevalence parasimpatotonus (59,0%) and simpatotonus (41,0%), and febrile reactions (71,2%) were more subfebrile with fever (51,2%).Conclusion: pathogenetic mechanisms of chronic course of Ixodes tick-borne borreliosis closely associated with inflammation and immune-mediated reactions of the organism , and are characterized by the presence of cellular immunodeficiency, insolvency phagocytosis, suppression of the synthesis of interleukin-4 and interleukin-8 intensive products. |
