| Autor: |
Hamdy Awad, Esmerina Tili, Gerard Nuovo, Hesham Kelani, Mohamed Ehab Ramadan, Jim Williams, Katherine Binzel, Jayanth Rajan, David Mast, Alexander A. Efanov, Kareem B. Rasul, Sarah Moore, Michele Basso, Adel Mikhail, Mostafa Eltobgy, Raphael A. Malbrue, Eric Bourekas, Michael Oglesbee, Valerie Bergdall, Michael Knopp, Jean-Jacques Michaille, Hosam El-Sayed |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-021-87324-6 |
| Popis: |
Abstract Both endovascular repair (EVR) and open repair (OR) surgery of thoraco-abdominal aortic aneurysms cause spinal cord (SC) injury that can lead to paraparesis or paraplegia. It has been assumed that mechanisms responsible for SC damage after EVR are similar to those after OR. This pilot study compared the pathophysiology of SC injury after EVR versus OR using a newly developed EVR dog model. An increasing number of stents similar to those used in patients were inserted in the aorta of three dogs to ensure thoracic or thoracic plus lumbar coverage. The aorta of OR dogs was cross-clamped for 45 min. Behavior assessment demonstrated unique patterns of proprioceptive ataxia and evolving paraparesis in EVR versus irreversible paraplegia in OR. MRI showed posterior signal in lumbar SC after EVR versus central cord edema after OR. Histopathology showed white matter edema in L3–L5 localized to the dorsal column medial lemniscus area associated with loss of myelin basic protein but not neurons after EVR, versus massive neuronal loss in the gray matter in L3–L5 after OR. Metabolome analysis demonstrates a distinctive chemical fingerprint of cellular processes in both interventions. Our results call for the development of new therapeutics tailored to these distinct pathophysiologic findings. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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