| Autor: |
Alka Bhardwaj, Sudhindra Dharmavaram, Sonia Wadhawan, Anjali Sethi, Poonam Bhadoria |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Journal of Anaesthesiology Clinical Pharmacology, Vol 27, Iss 2, Pp 247-248 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
0970-9185 |
| DOI: |
10.4103/0970-9185.81833 |
| Popis: |
A 74-year-old female with diabetes mellitus type II and Alzheimer′s disease, taking donepezil for 4 months was operated for right modified radical mastectomy under general anesthesia. During the procedure a higher dose of non-depolarizing muscle relaxant was required than those recommended for her age yet the muscle relaxation was inadequate intra-operatively. Residual neuromuscular blockade persisted postoperatively, due to the cumulative effect of large doses of non-depolarizing muscle relaxant, needing post-operative ventilatory assistance. After ruling out other causes of resistance to non-depolarizing muscle relaxants, we concluded that acetylcholinesterase inhibitor donepezil was primarily responsible for inadequate muscle relaxation and delayed post-operative neuromuscular recovery. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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