Infliximab-Associated Chronic Inflammatory Central Nervous System Disease and Peroneal Nerve Injury in a Psoriatic Patient Refractory to Treatment: Case Report with 10-Year Follow-Up

Autor: Sandra C. Signore, Birka Brauns, Gunther Schütze, Christoph P. Dohm, Mathias Bähr, Rotraut Mössner, Pawel Kermer
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Case Reports in Neurology, Vol 10, Iss 1, Pp 12-17 (2018)
Druh dokumentu: article
ISSN: 1662-680X
DOI: 10.1159/000485499
Popis: The tumor necrosis factor-α (TNF-α) antagonists infliximab, adalimumab, and etanercept have been approved for the treatment of chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, psoriasis, and psoriatic arthritis. Manifestations of demyelinating disease have been reported for patients receiving TNF-α antagonists. We describe a rare manifestation of a chronic inflammatory process affecting both the central and peripheral nervous system in a patient who received infliximab for the treatment of psoriasis and psoriatic arthritis. Infliximab therapy was discontinued and symptoms improved under high-dose intravenous glucocorticoid pulse therapy.
Databáze: Directory of Open Access Journals