| Autor: |
Valentín Ortiz-Maldonado, Gerard Frigola, Marta Español-Rego, Olga Balagué, Nuria Martínez-Cibrián, Laura Magnano, Eva Giné, Mariona Pascal, Juan G. Correa, Alexandra Martínez-Roca, Joan Cid, Miquel Lozano, Neus Villamor, Daniel Benítez-Ribas, Jordi Esteve, Armando López-Guillermo, Elías Campo, Álvaro Urbano-Ispizua, Manel Juan, Julio Delgado |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Frontiers in Oncology, Vol 12 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2234-943X |
| DOI: |
10.3389/fonc.2022.828471 |
| Popis: |
CART19 cells are emerging as an alternative therapy for patients with chronic lymphocytic leukemia (CLL). Here we report the outcome of nine consecutive patients with CLL treated with ARI-0001 CART19 cells, six of them with Richter’s transformation (RT). One patient with RT never received therapy. The cytokine release syndrome rate was 87.5% (12.5% grade ≥3). Neurotoxicity was not observed in any patient. All patients experienced absolute B-cell aplasia, and seven (87.5%) responded to therapy. With a median follow-up of 5.6 months, two patients with RT experienced a CD19-negative relapse. In conclusion, ARI-0001 cell therapy was feasible, safe, and effective in patients with high-risk CLL or RT. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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