Prognostic utility of preimplantation kidney biopsy from deceased older donors in first year post-transplant renal function

Autor: Juan J. Amenábar, Jhon A. Camacho, Nerea Gómez-Larrambe, Teresa Visus, José I. Pijoan, Jaime González del Tánago, Sofía Zárraga, Jorge García-Olaverri, Francisco J. Gaínza
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nefrología (English Edition), Vol 36, Iss 1, Pp 33-41 (2016)
Druh dokumentu: article
ISSN: 2013-2514
DOI: 10.1016/j.nefroe.2015.03.006
Popis: Background: Preimplantation renal biopsy provides potentially valuable information about post-transplant renal function. Objective: To assess the prognostic value of preimplantation kidney biopsy from older donors in determining 1-year post-transplant estimated glomerular filtration rate MDRD-4 (eGFR). Methods: We evaluated a cohort of 124 renal transplant recipients from deceased donors ≥60 years old, performed at our centre between March 2008 and May 2012. Biopsies were assessed by applying the score proposed by O’Valle et al. The overall score was stratified into 3 levels: 0–3, 4–5 and 6–8 points. Kidneys scoring >8 points were discarded. A total of 77% of the donors were ≥70 years. Results: One year post-transplant, mean eGFR (SD) was lower in transplant recipients with 6–8 points (38.5 [14.1] ml/min/1.73 m2) than in the group scoring 4–5 points (46.3 [15.7] [p = 0.03]) and the group scoring 0–3 (49.6 [12.5] [p = 0.04]). Seven patients (19%) had eGFR
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