Prognostic implication of human papillomavirus types in cervical cancer patients: a systematic review and meta-analysis

Autor:	Yuanyuan Xu, Yichao Qiu, Shuang Yuan, Hongjing Wang
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Human papillomavirus 16 Human papillomavirus 18 Survival Cervical cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Infectious and parasitic diseases RC109-216
Zdroj:	Infectious Agents and Cancer, Vol 15, Iss 1, Pp 1-9 (2020)
Druh dokumentu:	article
ISSN:	1750-9378
DOI:	10.1186/s13027-020-00332-5
Popis:	Abstract Background To estimate the prognostic relevance of human papillomavirus (HPV) 16 and HPV 18 in patients with cervical cancer. Method We searched PubMed, EMBASE, American Society of Clinical Oncology (ASCO) and the European Society of Medical Oncology (ESMO), CNKI, and Wanfang databases to search primary articles illustrating the survival outcomes in cervical cancer patients with or without HPV 16/18 infection. A meta-analysis was conducted to generate a combined hazard ratio (HR) with 95% confidence intervals (CI) for progression-free survival (PFS), disease free survival (DFS) and overall survival (OS). Results A total of 13 studies were included. Our meta-analysis revealed that HPV 16 positive did not have any impact on OS (HR, 0.76; 95% CI = 0.37–1.54; P = 0.44). Cervical cancer patiensts infected with HPV 18 had worse OS (HR, 1.66; 95% CI = 1.28–2.17; P = 0.0001), DFS (HR, 2.10; 95% CI = 1.73–2.54; P
Databáze:	Directory of Open Access Journals
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