Method for Quantitative Broadband Diffuse Optical Spectroscopy of Tumor-Like Inclusions
| Autor: | Sandhya Vasudevan, Farnoush Forghani, Chris Campbell, Savannah Bedford, Thomas D. O’Sullivan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
diffuse optical spectroscopy
hyperspectral diffuse optical imaging hybrid frequency-domain (fd) continuous-wave (cw) method diffuse optical imaging multispectral imaging broadband imaging Technology Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 |
| Zdroj: | Applied Sciences, Vol 10, Iss 4, p 1419 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2076-3417 10041419 |
| DOI: | 10.3390/app10041419 |
| Popis: | A hybrid reflectance-based diffuse optical imaging (DOI) technique combining discrete wavelength frequency-domain (FD) near-infrared spectroscopy (NIRS) with broadband continuous wave NIRS measurements was developed to quantify the broadband optical properties of deep tumor-like inclusions. This method was developed to more accurately measure the broadband optical properties of human tumors using a compact handheld imaging probe and without requiring a priori spectral constraints. We simulated the reconstruction of absorption and scattering spectra (650−1000 nm) of human breast tumors in a homogeneous background at depths of 0 to 10 mm. The hybrid DOI technique demonstrated enhanced performance in reconstruction of optical absorption with a mean accuracy over all 71 wavelengths of 8.39% versus 32.26% for a 10 mm deep tumor with the topographic DOI method. The new hybrid technique was also tested and validated on two heterogeneous tissue-simulating phantoms with inclusion depths of 2, 7, and 9 mm. The mean optical absorption accuracy over all wavelengths was similarly improved up to 5x for the hybrid DOI method versus topographic DOI for the deepest inclusions. |
| Databáze: | Directory of Open Access Journals |
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