Peripheral endocannabinoids in eating disorders and obesity and its relationship with clinical and anthropometric variables
| Autor: | I. Baenas-Soto, R. Miranda-Olivos, L. Vos, R. Granero, I. Sánchez, N. Riesco, A. Del Pino-Gutiérrez, E. Codina, J. A. Fernández-Formoso, N. Vilarrasa, N. Virgili, R. Lopez-Urdiales, A. Pastor, R. De La Torrre, S. Jimenez-Murcia, C. Soriano-Mas, F. Fernandez-Aranda |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | European Psychiatry, Vol 64, Pp S115-S115 (2021) |
| Druh dokumentu: | article |
| ISSN: | 0924-9338 1778-3585 |
| DOI: | 10.1192/j.eurpsy.2021.329 |
| Popis: | Introduction Anandamide (AEA) and 2-Arachidonoylglycerol (2-AG) play a pivotal role in food intake and reward aspects of feeding. Aberrant functioning in the endocannabinoid system has been observed in patients with eating disorders (EDs). This dysfunction may influence the incentive processes stimulating behaviors towards food acquisition or the hedonic evaluation of ingested food. Objectives The aims of this study are to compare fasting peripheral levels of AEA and 2-AG in ED patients, obese subjects (OB) and healthy controls (HCs), and to explore their association with clinical and anthropometric variables. Methods The sample included a total of 63 adult women. Peripheral blood samples were collected to investigate fasting levels of AEA and 2-AG in 31 ED patients: 22 Anorexia Nervosa (AN) and 9 Binge Eating Disorder (BED), compared to 21 OB and 11 HCs. Several clinical and anthropometric variables were also assessed. Results Comparing groups, significant differences in AEA levels were found (p=0.001). Specifically, individuals with AN exhibited lower AEA than OB (p |
| Databáze: | Directory of Open Access Journals |
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