Fibrillary Glomerulopathy with a High Level of Myeloperoxidase-ANCA: A Case Report

Autor:	Tomohiko Asakawa, Mea Asou, Shigeo Hara, Takashi Ehara, Makoto Araki
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Diseases of the genitourinary system. Urology RC870-923
Zdroj:	Case Reports in Nephrology, Vol 2020 (2020)
Druh dokumentu:	article
ISSN:	2090-6641 2090-665X
DOI:	10.1155/2020/6343521
Popis:	An elderly woman was admitted with the chief complaint of gross hematuria. Laboratory values indicated a high myeloperoxidase-ANCA level. In renal histological examination, 40% of the glomeruli showed crescent formation, but immunofluorescence staining showed positivity for IgG, C3, and C1q. Furthermore, the deposition of fibrils in the glomerulus was noted on electron microscopy, and immunohistochemical staining showed strong positivity for DNA-J heat shock protein family member B9 (DNAJB9). Crescent formation is a common feature of fibrillary glomerulonephritis (FGN). Thus, in ANCA-positive crescentic glomerulonephritis, immunohistochemical assessments for immunoglobulins and DNAJB9, as well as electron microscopy, are important to correctly diagnose FGN.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/6147219c38774990a81fedc84ff4c71f Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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