| Autor: |
Clément Aveneau, David Wallon, Bertrand Degos, Alexandre Obadia, Claire Hourregue, Sarah Benisty, Béatrice Garcin, Julien Dumurgier, Claire Paquet |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-8 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1758-9193 |
| DOI: |
10.1186/s13195-023-01305-7 |
| Popis: |
Abstract Introduction The first predominant clinical symptoms of dementia with Lewy bodies (DLB) are highly variable; however, the prognosis based on initial predominant symptoms remains poorly understood. Methods Multicenter retrospective study in 4 French expert neurological centers. Patients were categorized in 3 groups according to their first more predominant symptoms: cognitive, psychiatric, or motor. Results Analysis of 310 DLB patients. The mean age was 73.5 years old (SD 7.5) including 32.3% of women. The mean follow-up was 7.25 years (SD 3.6). We observed that the full clinical picture was more frequent in the motor group than in the cognitive group (p = 0.01); male gender and age at onset were associated with a significant excess risk of instantaneous mortality (p = 0.01). Conclusion Initial symptoms may affect the clinical course of patients, but no significant difference in mortality was observed. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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