Rates and Determinants for the Use of Anticoagulation Treatment before Stroke in Patients with Known Atrial Fibrillation

Autor: Michela Giustozzi, Giancarlo Agnelli, Silvia Quattrocchi, Monica Acciarresi, Andrea Alberti, Valeria Caso, Maria Cristina Vedovati, Michele Venti, Maurizio Paciaroni
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Cerebrovascular Diseases Extra, Vol 10, Iss 2, Pp 44-49 (2020)
Druh dokumentu: article
ISSN: 1664-5456
DOI: 10.1159/000506923
Popis: Introduction and Objective: Even though the introduction of less cumbersome anticoagulant agents has improved, the rates ofoverall anticoagulant treatment in eligible patients with atrial fibrillation (AF) remain to be defined. We aimed to assess the rates of and determinants for the use of anticoagulation treatment before stroke in patients with known AF since the introduction of direct oral anticoagulants (DOAC) in clinical practice. Methods: Consecutive patients admitted to an individual stroke unit, from September 2013 through July 2019, for acute ischemic stroke or transient ischemic attack (TIA) with known AF before the event were included in the study. Logistic regression analysis was used to identify independent predictors of the use of anticoagulant treatment. Results: Overall, 155 patients with ischemic stroke/TIA and known AF were included in this study. Among 152 patients with a CHA2DS2-VASc score >1, 43 patients were not receiving any treatment, 47 patients were receiving antiplatelet agents, and the remaining 62 patients were on oral anticoagulants. Among 34 patients on DOAC, 13 were receiving a nonlabeled reduced dose and 18 out of 34 patients on vitamin K antagonists had an INR value
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