Pilot study in human healthy volunteers on the use of magnetohydrodynamics in needle-free continuous glucose monitoring

Autor: Tuuli A. Hakala, Laura K. Zschaechner, Risto T. Vänskä, Teemu A. Nurminen, Melissa Wardale, Jonathan Morina, Zhanna A. Boeva, Reeta Saukkonen, Juha-Matti Alakoskela, Kim Pettersson-Fernholm, Edward Hæggström, Johan Bobacka, Alejandro García Pérez
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-022-21424-9
Popis: Abstract The benefits of continuous glucose monitoring (CGM) in diabetes management are extensively documented. Yet, the broader adoption of CGM systems is limited by their cost and invasiveness. Current CGM devices, requiring implantation or the use of hypodermic needles, fail to offer a convenient solution. We have demonstrated that magnetohydrodynamics (MHD) is effective at extracting dermal interstitial fluid (ISF) containing glucose, without the use of needles. Here we present the first study of ISF sampling with MHD for glucose monitoring in humans. We conducted 10 glucose tolerance tests on 5 healthy volunteers and obtained a significant correlation between the concentration of glucose in ISF samples extracted with MHD and capillary blood glucose samples. Upon calibration and time lag removal, the data indicate a Mean Absolute Relative Difference (MARD) of 12.9% and Precision Absolute Relative Difference of 13.1%. In view of these results, we discuss the potential value and limitations of MHD in needle-free glucose monitoring.
Databáze: Directory of Open Access Journals
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