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Jinfang Wang,1,2 Yi Liang,2 Hongyan Chen,1 Wanming Wang,2 Yanwen Wang,2 Ying Liang,3 Yumei Zhang1,4 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China; 2Department of Neurology, General Hospital of The Yang Tze River Shipping, Wuhan Brain Hospital, Wuhan 430000, China; 3School of Biomedical Engineering, Capital Medical University, Beijing 100050, China; 4Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China Background: White matter lesions (WMLs) play a role in cognitive decline and dementia. Little is known about gray matter (GM) changes in WMLs. This study aimed to investigate GM changes in WML patients. Materials and methods: Correlations between altered structural volume and cognitive assessment scores were investigated. GM and white matter (WM) changes in 23 WML-vascular dementia (VaD) patients, 22 WML-non-dementia vascular cognitive impairment (VCIND) patients, and 23 healthy control (HC) subjects were examined. Gray matter density (GMD) was calculated by measuring local proportions of GM at thousands of homologous cortical locations. WM volume was obtained by fully automated software using voxel-based morphometry (VBM). Results: Widespread GMD was significantly lower in WML patients compared to control subjects in cortical and subcortical regions (p0.05). Conclusion: GMD and WM volume were changed in WMLs, and the changes were detectable. Correlation between structural changes and cognitive function was promising in understanding the pathological and physiological mechanisms of WMLs. Keywords: white matter lesions, vascular dementia, gray matter density, dementia |
