| Autor: |
Nina D. Arhin, Chan Shen, Christina E. Bailey, Lea K. Matsuoka, Alexander T. Hawkins, Andreana N. Holowatyj, Kristen K. Ciombor, Michael B. Hopkins, Timothy M. Geiger, Audrey E. Kam, Marc T. Roth, Cody M. Lebeck Lee, Michael Lapelusa, Arvind Dasari, Cathy Eng |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Cancer Medicine, Vol 10, Iss 13, Pp 4269-4281 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-7634 |
| DOI: |
10.1002/cam4.3940 |
| Popis: |
Abstract Background The incidence of colorectal cancer in adults younger than age 50 has increased with rates expected to continue to increase over the next decade. The objective of this study is to examine the survival benefit of surgical resection (primary and/or metastatic) versus palliative therapy in this patient population. Methods We identified 6708 young adults aged 18–45 years diagnosed with metastatic colorectal cancer (mCRC) from 2004 to 2015 from the SEER database. Overall survival (OS) was analyzed using Kaplan–Meier estimation, log rank test, and multivariate Cox proportional hazards model. Results Sixty‐three percent of patients in our study underwent primary tumor resection (PTR), with 40% undergoing PTR alone and 23% undergoing both resection of primary disease and metastasectomy. The median OS for patients who underwent both PTR and metastasectomy was 36 months, compared to 13 months for those who did not receive any surgical intervention. The multivariate analysis showed significant OS benefit of receiving both PTR and metastasectomy (HR 0.34, 95% CI: 0.31–0.37, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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