| Autor: |
Serdar AKKOL, Mehmet Can DOĞAN, Duygu ESENKAR, Handan DOĞAN, Tuğba KARAMAHMUTOĞLU, Filiz ONAT |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Archives of Epilepsy, Vol 23, Iss 2, Pp 51-56 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2792-0550 |
| DOI: |
10.14744/epilepsi.2017.59389 |
| Popis: |
Objectives:Probiotics are microorganisms of intestinal microflora that are beneficial for human health. Childhood absence epilepsy has 2 validated rat models: Genetic Absence Epilepsy Rats from Strasbourg (GAERS) and Wistar Albino Glaxo from Rijswijk (WAG/Rij). To date, there have been no clinical or experimental studies of the effects of probiotics on absence epilepsy. The present study was an investigation of the effects of probiotics on absence seizures in the GAERS rat model.Methods:GAERS were used to examine the effects of probiotics. Nine male GAERS were assigned to 1 of 2 groups (probiotic or control). The animals had free access to food and water. Commercially available probiotic product was provided in drinking water to probiotic group for 1 month. Surface electrodes were then implanted for electroencephalogram (EEG) recordings. Two aspects of EEG recordings were compared: cumulative duration and cumulative number of absence seizures.Results:Analysis of spike-and-wave discharges between the 2 groups showed no significant difference in either cumulative duration or number (p>0.05). Additionally, it was observed that probiotic group consumed more water than control group (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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