Dissection of gene expression datasets into clinically relevant interaction signatures via high-dimensional correlation maximization

Autor: Michael Grau, Georg Lenz, Peter Lenz
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-12713-5
Popis: Identification of clinically relevant gene expression signatures for cancer stratification remains challenging. Here, the authors introduce a flexible nonlinear signal superposition model that enables dissection of large gene expression data sets into signatures and extraction of gene interactions.
Databáze: Directory of Open Access Journals