Circulating Gal‐3 and sST2 are associated with acute exercise‐induced sustained endothelial activation: Possible relevance for fibrosis development?

Autor: Julia M. Kröpfl, Fernando G. Beltrami, Hans‐Jürgen Gruber, Arno Schmidt‐Trucksäss, Thomas Dieterle, Christina M. Spengler
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Experimental Physiology, Vol 108, Iss 10, Pp 1259-1267 (2023)
Druh dokumentu: article
ISSN: 1469-445X
0958-0670
DOI: 10.1113/EP091277
Popis: Abstract Long‐term, intense endurance exercise training can occasionally induce endothelial micro‐damage and cardiac fibrosis. The underlying mechanisms are incompletely understood. Twenty healthy, well‐trained male participants (10 runners and 10 cyclists) performed a strenuous high‐intensity interval training (HIIT) session matched by age, height, weight and maximal oxygen consumption. We assessed the acute exercise response of novel cardiac biomarkers of fibrosis [e.g., galectin‐3 (Gal‐3) and soluble suppression of tumorigenicity 2 (sST2)] per exercise modality and their relationship with haemodynamic contributors, such as preload, afterload and cardiac contractility index (CTi), in addition to endothelial damage by sustained activation and shedding of endothelial cells (ECs). Serum Gal‐3 and sST2 concentrations were investigated by enzyme‐linked immunosorbent assays; haemodynamics were analysed via impedance plethysmography and circulating ECs by flow cytometry. The Gal‐3 and sST2 concentrations and ECs were elevated after exercise (P
Databáze: Directory of Open Access Journals
Externí odkaz: