| Autor: |
Mareike Gastl, Alexander Gotschy, Jochen von Spiczak, Malgorzata Polacin, Florian Bönner, Christiane Gruner, Malte Kelm, Frank Ruschitzka, Hatem Alkadhi, Sebastian Kozerke, Robert Manka |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
European Journal of Radiology Open, Vol 6, Iss , Pp 78-84 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2352-0477 |
| DOI: |
10.1016/j.ejro.2019.01.007 |
| Popis: |
Purpose: Hypertrophic cardiomyopathy (HCM) is characterized by a heterogeneous morphology and variable prognosis. A mismatch between left ventricular mass (LVM) and microvascular circulation with corresponding relative ischemia has been implicated to cause myocardial replacement fibrosis that deteriorates prognosis. Besides parametric T1 mapping, Cardiovascular Magnetic Resonance (CMR) T2* mapping is able to identify ischemia as well as fibrosis in cardiac and extracardiac diseases. Therefore, we aimed to investigate the value of T2* mapping to characterize structural alterations in patients with HCM. Methods: CMR was performed on a 1.5 T MR imaging system (Achieva, Philips, Best, Netherlands) using a 5-channel coil in patients with HCM (n = 103, 50.6 ± 16.4 years) and in age- and gender-matched controls (n = 20, 44.8 ± 16.9 years). T2* mapping (1 midventricular short axis slice) was acquired in addition to late gadolinium enhancement (LGE). T2* values were compared between patients with HCM and controls as well as between HCM patients with- and without fibrosis. Results: HCM patients showed significantly decreased T2* values compared to controls (26.2 ± 4.6 vs. 31.3 ± 4.3 ms, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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