Monkeypox: a systematic review of epidemiology, pathogenesis, manifestations, and outcomes
| Autor: | SeyedAhmad SeyedAlinaghi, Amir Masoud Afsahi, Arian Afzalian, Ramin Shahidi, Seyed Saeed Tamehri Zadeh, Sanaz Varshochi, Mohsen Dashti, Afsaneh Ghasemzadeh, Ava Pashaei, Parinaz Paranjkhoo, Zohal Parmoon, Sahar N. Parikhani, Ahmadreza Shamsabadi, Pourya Pezeshgi, Sepide Ahmadi, Ghazal Arjmand, Mohammad Javaherian, Hooman Ebrahimi, Amirali Karimi, Esmaeil Mehraeen, Shayesteh Jahanfar |
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| Jazyk: | ruština |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Инфекция и иммунитет, Vol 13, Iss 6, Pp 1169-1186 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2220-7619 2313-7398 |
| DOI: | 10.15789/2220-7619-MAS-15632 |
| Popis: | Introduction. Since May 2022, an unusually large number of new monkeypox infections-a previously rare viral zoonotic disease, mainly reported from central and western Africa has been reported globally, and the World Health Organization (WHO) declared a global health emergency in July 2022. We aimed to systematically review the monkeypox virus epidemiology, pathogenesis, transmission, presentations, and outcomes. Materials and methods. Our aim is to systematically review the epidemiology, pathogenesis, manifestations, and outcomes of Monkeypox disease. We searched the keywords in the online databases of PubMed, Embase, Scopus, and Web of Science and investigated all English articles until December 2022. In order to ascertain the findings, this study adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. In order to optimize the quality, this review study benefits from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. To minimize any probable bias risk, we utilized the Newcastle-Ottawa Scale (NOS) risk assessment tool. Results. The most prevalent symptoms were rash and fever. The infection was accompanied by different complications such as, but not limited to, encephalitis (mainly in children), septicemia, bacterial cellulitis, retropharyngeal and parapharyngeal abscesses, etc. A wide range of hospitalization from 3.7% to 100% has been reported. The mortality rate ranged from 0% to 23%, which mainly occurred in infants and children. High mortality of the monkeypox rate was reported among pregnant women. The mortality rate of monkeypox is lower among women and those who received the smallpox vaccine compared to men and those who did not receive the vaccine. A wide range of the overall second-rate attack was reported, which is more pronounced in unvaccinated patients. Conclusion. In our systematic review of 35 studies on monkeypox, we cast light on the existing evidence on its epidemiology, pathogenesis, manifestation, and outcomes. Further studies are needed to elucidate the natural history of the disease in various patients’ population, as well as detailing the monkeypox attack rate. |
| Databáze: | Directory of Open Access Journals |
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