Myocardial Vasculitis Associated With the Immune Checkpoint Inhibitor Pembrolizumab

Autor: Hideo Oishi, MD, Ryota Morimoto, MD, PhD, Yoshie Shimoyama, MD, PhD, Kei Kuroda, MD, Toru Urata, MD, Toru Kondo, MD, PhD, Takahiro Okumura, MD, PhD, Yasuko K. Bando, MD, PhD, Masashi Akiyama, MD, PhD, Toyoaki Murohara, MD, PhD
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: JACC: Case Reports, Vol 2, Iss 12, Pp 1937-1941 (2020)
Druh dokumentu: article
ISSN: 2666-0849
DOI: 10.1016/j.jaccas.2020.07.028
Popis: Recent developments in immune checkpoint inhibitors (ICIs) have provided new treatment strategies for advanced cancer. However, ICIs lead to an imbalance between T cell–mediated inflammatory responses and immune tolerance in the myocardium. Here we report the first case that implicates the contribution of ICI-induced vasculitis to myocardial injury. (Level of Difficulty: Intermediate.)
Databáze: Directory of Open Access Journals