| Autor: |
Vasileios Kollaras, Georgia Valsami, Maria Lambropoulou, Ourania Konstandi, Nikolaos Kostomistsopoulos, Emmanouil Pikoulis, Constantinos Simopoulos, Alexandra Tsaroucha |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Acta Cirúrgica Brasileira, Vol 36, Iss 9 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
0102-8650 |
| DOI: |
10.1590/acb360904 |
| Popis: |
ABSTRACT Purpose: The protective effect of silibinin on kidney and lung parenchyma during hepatic ischemia/reperfusion injury (IRI) is explored. Methods: Sixty-three Wistar rats were separated into three groups: sham; control (45 min IRI); and silibinin (200 μL silibinin administration after 45 min of ischemia and before reperfusion). Immunohistochemistry and real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) were used to evaluate the expression levels of MMP2, MMP3, MMP9, and TIMP2 on kidney and lung. Results: Comparing sham vs. control groups, confirmed that hepatic IRI increased both renal and lung MMP2, MMP3, MMP9 and TIMP2 expressions starting at 180 min (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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