| Autor: |
Lindsay S. Cahill, Greg Stortz, Anjana Ravi Chandran, Natasha Milligan, Shiri Shinar, Clare L. Whitehead, Sebastian R. Hobson, Viji Ayyathurai, Anum Rahman, Rojan Saghian, Karl J. Jobst, Cyrethia McShane, Dana Block-Abraham, Viola Seravalli, Melissa Laurie, Sarah Millard, Cassandra Delp, Denise Wolfson, Ahmet A. Baschat, Kellie E. Murphy, Lena Serghides, Eric Morgen, Christopher K. Macgowan, W.Tony Parks, John C. Kingdom, John G. Sled |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
EBioMedicine, Vol 67, Iss , Pp 103326- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2352-3964 |
| DOI: |
10.1016/j.ebiom.2021.103326 |
| Popis: |
Background: The umbilical artery (UA) Doppler pulsatility index is used clinically to detect elevated feto-placental vascular resistance. However, this metric is confounded by variation in fetal cardiac function and is only moderately predictive of placental pathology. Our group developed a novel ultrasound methodology that measures wave reflections in the UA, thereby isolating a component of the Doppler signal that is specific to the placenta. The present study examined whether wave reflections in the UA are predictive of placental vascular pathology. Methods: Standard clinical Doppler ultrasound of the UAs was performed in 241 pregnant women. Of these, 40 women met narrowly defined preset criteria for the control group, 36 had maternal vascular malperfusion (MVM) and 16 had fetal vascular malperfusion (FVM). Using a computational procedure, the Doppler waveforms were decomposed into a pair of forward and backward propagating waves. Findings: Compared to controls, wave reflections were significantly elevated in women with either MVM (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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