Phosphorylation of PSD-95 at serine 73 in dCA1 is required for extinction of contextual fear.

Autor: Magdalena Ziółkowska, Malgorzata Borczyk, Anna Cały, Kamil F Tomaszewski, Agata Nowacka, Maria Nalberczak-Skóra, Małgorzata Alicja Śliwińska, Kacper Łukasiewicz, Edyta Skonieczna, Tomasz Wójtowicz, Jakub Wlodarczyk, Tytus Bernaś, Ahmad Salamian, Kasia Radwanska
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: PLoS Biology, Vol 21, Iss 5, p e3002106 (2023)
Druh dokumentu: article
ISSN: 1544-9173
1545-7885
DOI: 10.1371/journal.pbio.3002106
Popis: The updating of contextual memories is essential for survival in a changing environment. Accumulating data indicate that the dorsal CA1 area (dCA1) contributes to this process. However, the cellular and molecular mechanisms of contextual fear memory updating remain poorly understood. Postsynaptic density protein 95 (PSD-95) regulates the structure and function of glutamatergic synapses. Here, using dCA1-targeted genetic manipulations in vivo, combined with ex vivo 3D electron microscopy and electrophysiology, we identify a novel, synaptic mechanism that is induced during attenuation of contextual fear memories and involves phosphorylation of PSD-95 at Serine 73 in dCA1. Our data provide the proof that PSD-95-dependent synaptic plasticity in dCA1 is required for updating of contextual fear memory.
Databáze: Directory of Open Access Journals
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