The 'Gender Factor' in Wearing-Off among Patients with Parkinson’s Disease: A Post Hoc Analysis of DEEP Study

Autor: Delia Colombo, Giovanni Abbruzzese, Angelo Antonini, Paolo Barone, Gilberto Bellia, Flavia Franconi, Lucia Simoni, Mahmood Attar, Emanuela Zagni, Shalom Haggiag, Fabrizio Stocchi
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: The Scientific World Journal, Vol 2015 (2015)
Druh dokumentu: article
ISSN: 2356-6140
1537-744X
DOI: 10.1155/2015/787451
Popis: Background. The early detection of wearing-off in Parkinson disease (DEEP) observational study demonstrated that women with Parkinson’s disease (PD) carry an increased risk (80.1%) for wearing-off (WO). This post hoc analysis of DEEP study evaluates gender differences on WO and associated phenomena. Methods. Patients on dopaminergic treatment for ≥1 year were included in this multicenter observational cross-sectional study. In a single visit, WO was diagnosed based on neurologist assessment as well as the use of the 19-item wearing-off questionnaire (WOQ-19); WO was defined for scores ≥2. Post hoc analyses were conducted to investigate gender difference for demographic and clinical features with respect to WO. Results. Of 617 patients enrolled, 236 were women and 381 were men. Prevalence of WO was higher among women, according to both neurologists’ judgment (61.9% versus 53.8%, P=0.045) and the WOQ-19 analysis (72.5% versus 64.0%, P=0.034). In patients with WO (WOQ-19), women experienced ≥1 motor symptom in 72.5% versus 64.0% in men and ≥1 nonmotor symptom in 44.5% versus 36.7%, in men. Conclusions. Our results suggest WO as more common among women, for both motor and nonmotor symptoms. Prospective studies are warranted to investigate this potential gender-effect.
Databáze: Directory of Open Access Journals
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