Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response

Autor: Krist Helen Antunes, José Luís Fachi, Rosemeire de Paula, Emanuelle Fraga da Silva, Laís Passariello Pral, Adara Áurea dos Santos, Greicy Brisa Malaquias Dias, José Eduardo Vargas, Renato Puga, Fabiana Quoos Mayer, Fábio Maito, Carlos R. Zárate-Bladés, Nadim J. Ajami, Marcella Ramos Sant’Ana, Thamiris Candreva, Hosana Gomes Rodrigues, Marcio Schmiele, Maria Teresa Pedrosa Silva Clerici, José Luiz Proença-Modena, Angélica Thomas Vieira, Charles R. Mackay, Daniel Mansur, Mauricio T. Caballero, Jacqui Marzec, Jianying Li, Xuting Wang, Douglas Bell, Fernando P. Polack, Steven R. Kleeberger, Renato T. Stein, Marco Aurélio Ramirez Vinolo, Ana Paula Duarte de Souza
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Druh dokumentu: article
ISSN: 2041-1723
76919412
DOI: 10.1038/s41467-019-11152-6
Popis: Dietary fibers and SCFAs can exert a protective effect against respiratory syncytial virus (RSV). Here, the authors report that microbiota-derived acetate protects mice against RSV infection via GPR43- mediated type 1 interferon response induction in the lungs.
Databáze: Directory of Open Access Journals