Growth performance and reproductive function impairment of glyphosate‐based herbicide in male guinea pig (Cavia porcellus)

Autor: Valence Bwana Mutwedu, Albert Wafula Nyongesa, Pascaline Ciza Azine, Daniel Katulanya Chiregereza, Victor Herman Ngoumtsop, Yannick Mugumaarhahama, Rodrigue Basengere Balthazar Ayagirwe
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Veterinary Medicine and Science, Vol 7, Iss 3, Pp 1047-1055 (2021)
Druh dokumentu: article
ISSN: 2053-1095
DOI: 10.1002/vms3.443
Popis: Abstract Glyphosate formulations, widely applied non‐selective systemic herbicides, are progressively becoming the most controversial pesticides on the market due the adverse effects they pose to humans and environment. The information on these potential hazardous effects to the handlers of the pesticide remains obscure. This study investigated effects of glyphosate‐based herbicide on growth performance, seminal parameters and hemato‐biochemical profiles in male guinea pig. Forty sexually mature male guinea pigs weighing between 393.3 and 418.4 g were divided into four groups of 10 animals each and orally administered 0, 186, 280 and 560 mg/kg body weight of WILLOSATE daily for 60 days. Daily feed intake and body weight gain were recorded. At the end of experimental period all animals were humanely sacrificed, and blood samples and vital organs were collected for appropriate analysis. Results showed a significant decrease (p
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