Analysing the mechanism of mitochondrial oxidation-induced cell death using a multifunctional iridium(III) photosensitiser

Autor: Chaiheon Lee, Jung Seung Nam, Chae Gyu Lee, Mingyu Park, Chang-Mo Yoo, Hyun-Woo Rhee, Jeong Kon Seo, Tae-Hyuk Kwon
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-20210-3
Popis: Mitochondrial oxidation-induced cell death is an important physiological process activated by cancer therapeutics, but its investigation is challenging. Here, the authors report a multifunctional iridium(III) photosensitiser, Ir-OA, able to induce mitochondrial oxidative stress and monitor the corresponding changes in mitochondrial properties.
Databáze: Directory of Open Access Journals