| Autor: |
Alexandra Elena Oprea, Loredana Mihaela Pandel, Ana Maria Dumitrescu, Ecaterina Andronescu, Valentina Grumezescu, Mariana Carmen Chifiriuc, Laurenţiu Mogoantă, Tudor-Adrian Bălşeanu, George Dan Mogoşanu, Gabriel Socol, Alexandru Mihai Grumezescu, Florin Iordache, Horia Maniu, Mariana Chirea, Alina Maria Holban |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Molecules, Vol 21, Iss 2, p 220 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1420-3049 |
| DOI: |
10.3390/molecules21020220 |
| Popis: |
Deposition of bioactive coatings composed of zinc oxide, cyclodextrin and cefepime (ZnO/CD/Cfp) was performed by the Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique. The obtained nanostructures were characterized by X-ray diffraction, IR microscopy and scanning electron microscopy. The efficient release of cefepime was correlated with an increased anti-biofilm activity of ZnO/CD/Cfp composites. In vitro and in vivo tests have revealed a good biocompatibility of ZnO/CD/Cfp coatings, which recommend them as competitive candidates for the development of antimicrobial surfaces with biomedical applications. The release of the fourth generation cephalosporin Cfp in a biologically active form from the ZnO matrix could help preventing the bacterial adhesion and the subsequent colonization and biofilm development on various surfaces, and thus decreasing the risk of biofilm-related infections. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
